Found the Signature of George W. Combs in the book:
Indiana Past and Present 1816 to 1916 100 Years of Progress [pg467]
 

WHO'S WHO IN INDIANA

GEORGE W COMBS, physician, born Oaklandon, Ind. March 10, 1859; grad Med Coll of Ind 1S84; Polyclinic, N Y, 1906; studied London, Berlin, Vienna and Paris 1901-6-11; assoc clin prof gastro-intest surg Ind Univ Sch Med; surg to city hosp rectal dis; mem A M A; Ind State; Indpls med socs; Fellow Am Proctol soc, etc; res Indpls.